Our Health Library information does not replace the advice of a doctor. Please be advised that this information is made available to assist our patients to learn more about their health. Our providers may not see and/or treat all topics found herein.


Pronunciation: dal FAM pri deen

Brand: Ampyra


slide 1 of 2, Ampyra,

10 mg, oval, white, imprinted with A10

Image of Ampyra
slide 1 of 2

Dalfampridine ER

slide 2 of 2, Dalfampridine ER,

10 mg, oval, white, imprinted with WPI, 2533

Image of Dalfampridine ER
slide 2 of 2

What is the most important information I should know about dalfampridine?

Dalfampridine can cause a seizure, even if you never had one before. Taking too much dalfampridine may increase your risk of seizure. Your risk may also be higher if you have kidney problems or are older than 50.

Your kidney function may need to be tested before you start taking this medicine.

Stop taking dalfampridine and call your doctor right away if you have a seizure.

What is dalfampridine?

Dalfampridine is used to improve walking in patients with multiple sclerosis (MS).

Dalfampridine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking dalfampridine?

You should not use this medicine if you are allergic to dalfampridine or 4-aminopyridine, or if you have:

  • moderate to severe kidney disease; or
  • if you've ever had a seizure.

Dalfampridine can cause a seizure, even if you never had one before. Your risk may also be higher if you have kidney problems or are older than 50.

Tell your doctor if you have ever had:

  • kidney disease; or
  • if you also take a form of this medicine obtained from a compounding pharmacy (fampridine, or 4-aminopyridine).

Older adults may be more sensitive to the effects of this medication.

It is not known if dalfampridine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Ask a doctor if it is safe to breastfeed while using this medicine.

Not approved for use by anyone younger than 18 years old.

How should I take dalfampridine?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Taking too much dalfampridine may increase your risk of seizure. Space your doses 12 hours apart. Do not take more than 2 tablets in 24 hours.

You may take dalfampridine with or without food.

Swallow the tablet whole and do not crush, chew, or break it. Breaking the pill may cause too much of the drug to be released at one time which can increase your risk of a seizure.

Do not use a tablet that has been crushed or broken.

Store at room temperature away from moisture and heat. Do not use past the expiration date on the label.

What happens if I miss a dose?

Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose can cause confusion or seizures.

What should I avoid while taking dalfampridine?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of dalfampridine?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop taking dalfampridine and call your doctor right away if you have a seizure.

Call your doctor at once if you have:

  • pain or burning when you urinate; or
  • relapse or worsening of MS symptoms.

Common side effects may include:

  • weakness, MS relapse;
  • painful urination;
  • dizziness, balance problems;
  • numbness or tingling;
  • sleep problems (insomnia);
  • nausea, constipation, upset stomach;
  • stuffy nose, sinus pain, sore throat; or
  • headache, back pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect dalfampridine?

Tell your doctor about all your other medicines, especially:

  • cimetidine.

This list is not complete. Other drugs may affect dalfampridine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your pharmacist can provide more information about dalfampridine.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 7.01. Revision date: 9/22/2021.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by End-User License Agreement, which can be accessed by clicking on this link.

phone number