Our Health Library information does not replace the advice of a doctor. Please be advised that this information is made available to assist our patients to learn more about their health. Our providers may not see and/or treat all topics found herein.


Pronunciation: KRIZ an LIZ ue mab

Brand: Adakveo

What is the most important information I should know about crizanlizumab?

Some side effects may occur within 24 hours after you receive this medicine. Tell your caregiver if you feel dizzy, nauseated, tired, itchy, chilled, sweaty, or have a fever, wheezing, or shortness of breath.

What is crizanlizumab?

Crizanlizumab is used in people with sickle cell disease to reduce how often certain episodes (vaso-occlusive crises) occur.

Crizanlizumab is for use in adults and children at least 16 years old.

Crizanlizumab may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before receiving crizanlizumab?

Tell your doctor if you are pregnant or plan to become pregnant. Having sickle cell disease during pregnancy may increase the risk of premature birth or low birth weight. The benefit of treating sickle cell disease may outweigh any risks to the baby.

Ask a doctor if it is safe to breastfeed while using this medicine.

How is crizanlizumab given?

Crizanlizumab is given as an infusion into a vein. A healthcare provider will give you this injection.

This medicine must be given slowly, and the infusion can take about 30 minutes to complete.

Your doctor may prescribe other treatments while using crizanlizumab.

Crizanlizumab is usually given once every 2 to 4 weeks. Follow your doctor's dosing instructions very carefully.

Do not stop using this medicine without your doctor´s advice.

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using crizanlizumab.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your crizanlizumab injection.

What happens if I overdose?

Since this medicine is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid while receiving crizanlizumab?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of crizanlizumab?

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Some side effects may occur within 24 hours after you receive this medicine. Call your doctor if you feel dizzy, nauseated, tired, itchy, chilled, sweaty, or have a fever, wheezing, or shortness of breath.

Common side effects may include:

  • stomach pain or tenderness;
  • nausea;
  • fever;
  • joint pain; or
  • back pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect crizanlizumab?

Other drugs may affect crizanlizumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all other medicines you use.

Where can I get more information?

Your doctor or pharmacist can provide more information about crizanlizumab.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2023 Cerner Multum, Inc. Version: 3.01. Revision date: 9/30/2022.

Your use of the content provided in this service indicates that you have read, understood and agree to the End-User License Agreement, which can be accessed by End-User License Agreement, which can be accessed by clicking on this link.

phone number