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amoxicillin, clarithromycin, and vonoprazan

Pronunciation: a MOX i SIL in, kla RITH roe MYE sin, von OH pra zan

Brand: Voquezna Triple Pak

What is the most important information I should know about amoxicillin, clarithromycin, and vonoprazan?

Tell your doctor about all your other medicines. Some drugs should not be used with amoxicillin, clarithromycin, and vonoprazan.

What is amoxicillin, clarithromycin, and vonoprazan (Voquezna Triple Pak)?

Amoxicillin, clarithromycin, and vonoprazan (Voquezna Triple Pak) is a combination medicine used to prevent stomach ulcer in adults caused by infection with Helicobacter pylori (H. pylori).

Amoxicillin, clarithromycin, and vonoprazan may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking Voquezna Triple Pak?

You should not use this medicine if you are allergic to amoxicillin, clarithromycin or vonoprazan, or similar medicines such as:

  • azithromycin, erythromycin, or telithromycin;
  • a penicillin antibiotic, including ampicillin, Augmentin, Principen, Timentin, Trimox, and others; or
  • a cephalosporin antibiotic such as cefdinir, cefprozil, cefuroxime, cephalexin, Duricef, Omnicef, Cefzil, Keflex, Spectracef, and others.

You should not use amoxicillin, clarithromycin, and vonoprazan if you have a history of cholestatic jaundice or liver problems with previous use of clarithromycin.

Some drugs should not be used with amoxicillin, clarithromycin, and vonoprazan. Your treatment plan may change if you also use:

  • rilpivirine-containing products;
  • pimozide;
  • cholesterol medication such as lomitapide, simvastatin, and lovastatin;
  • ergot alkaloids; or
  • colchicine (in people with kidney or liver problems).

Tell your doctor if you have ever had:

  • liver or kidney disease; or
  • myasthenia gravis.

Amoxicillin, clarithromycin, and vonoprazan may harm an unborn baby. Tell your doctor if you are pregnant or plan to get pregnant.

It may be harder for you to get a woman pregnant while you are using this medicine.

Do not breastfeed while using this medicine. If you use a breast pump during this time, throw out the milk and do not feed it to your baby for at least 2 days after your last dose.

How should I take Voquezna Triple Pak?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Each dose of this combination medication contains 3 pills (1 capsule and 2 tablets). Take all 3 pills twice daily (12 hours apart, in the morning and evening), with or without food for 14 days, unless your doctor tells you otherwise.

Keep using this medicine even if your symptoms quickly improve. Skipping doses could make your infection resistant to medication. Amoxicillin, clarithromycin, and vonoprazan will not treat a viral infection (flu or a common cold).

This medicine can affect the results of certain medical tests. Tell any doctor who treats you that you are using amoxicillin, clarithromycin, and vonoprazan.

Antibiotic medicines can cause diarrhea. Tell your doctor if you have diarrhea that is watery or bloody.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Use the medicine as soon as you can, but skip the missed dose if you are more than 4 hours late for the dose. Do not use two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Voquezna Triple Pak?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What are the possible side effects of Voquezna Triple Pak?

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include skin rash, fever, swollen glands, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes.

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
  • liver problems --swelling around your midsection, right-sided upper stomach pain, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • kidney problems --swelling, urinating less, feeling tired or short of breath; or
  • new or worsening symptoms of myasthenia gravis --weakness of the eye muscles, drooping of the eyelids, blurred vision, problems swallowing, impaired speech.

Older adults may be more sensitive to the effects of this medication.

Common side effects may include:

  • altered sense of taste;
  • diarrhea;
  • vaginal itching or discharge;
  • headache;
  • stomach pain; or
  • severe headache, blurred vision, pounding in your neck or ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Voquezna Triple Pak?

Sometimes it is not safe to use certain medicines at the same time. Some drugs can affect your blood levels of other drugs you use, which may increase side effects or make the medicines less effective.

Amoxicillin, clarithromycin, and vonoprazan can cause a serious heart problem. Your risk may be higher if you also use certain other medicines for infections, asthma, heart problems, high blood pressure, depression, mental illness, cancer, malaria, or HIV.

Tell your doctor about all your other medicines, especially:

  • insulin or oral diabetes medicine (especially nateglinide, pioglitazone, repaglinide, or rosiglitazone);
  • a blood thinner --warfarin (Coumadin, Jantoven);
  • probenecid;
  • omeprazole; or
  • itraconazole.

This list is not complete and many other drugs may affect amoxicillin, clarithromycin, and vonoprazan. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information?

Your doctor or pharmacist can provide more information about amoxicillin, clarithromycin, and vonoprazan.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2022 Cerner Multum, Inc. Version: 1.02. Revision date: 11/13/2022.

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